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Corticosteroids are critical for development and for mediating stress responses across diverse vertebrate taxa. Study of frog metamorphosis has made significant breakthroughs in our understanding of corticosteroid signaling during development in non-mammalian vertebrate species. However, lack of adequate corticosterone (CORT) response genes in tadpoles make identification and quantification of CORT responses challenging. Here, we characterized a CORT-response genefrzb(frizzled related protein) previously identified inXenopus tropicalistadpole tail skin by an RNA-seq study. We validated the RNA-seq results that CORT and not thyroid hormone inducesfrzbin the tails using quantitative PCR. Further, maximumfrzbexpression was achieved by 100-250 nM CORT within 12-24 hours.frzbis not significantly induced in the liver and brain in response to 100 nM CORT. We also found no change infrzbexpression across natural metamorphosis when endogenous CORT levels peak. Surprisingly,frzbis only induced by CORT inX. tropicalistails and not inXenopus laevistails. The exact downstream function of increasedfrzbexpression in tails in response to CORT is not known, but the specificity of hormone response and its high mRNA expression levels in the tail renderfrzba useful marker of exogenous CORT-response independent of thyroid hormone for exogenous hormone treatments andin-vivoendocrine disruption studies.